When Filipinos experience pandemics due to COVID-19, the educational system adjusted through the interim guidelines like changing for a while the teaching instructions into modular distance learning and the main learning resources are Self-Learning Modules (SLMs). In this study, the authors determined the adaptive coping strategies in learning General Mathematics Instruction through SLMs by Grade 11 students in Mayon National High School, School Year 2020-2021. The researcher applied descriptive design, utilizing both qualitative and quantitative methods of research. The respondents were 30 randomly selected Grade 11 students from two different strands. A questionnaire in checklist form was the main instrument in this study that was validated by 5 mathematics and language experts. This undertaken a reliability test using Cronbach Alpha Analysis with 0.87 value which means fairly high and reliable. The researcher also gathered existing data which are the final grades of the respondents in General Mathematics. The data gathered were tabulated and analyzed using frequency, percentage, weighted mean, standard deviation, Pearson correlation coefficient, and coefficient of determination. The authors concluded that the adaptive coping strategies employed by the students along with personal, family, environmental, peer, and finances in learning General Mathematics instruction through SLMs varied. The responses of the students in learning General Mathematics along with teacher and SLMs were mostly positive. In addition, there was a moderately significant relationship between adaptive coping strategies employed by the students along with personal factors while the other variables such as family, environment, peer, and finances were insignificant relationships on the performance level of students in General Mathematics through SLMs instructions. The problem observed was the poor foundation in Mathematics under personal factors which was the main focus on the action plan proposed by the author’s entitled Mathematics Tutorial: A Walk to Teach Amidst Pandemic.