The study presented in this paper sought to determine the factors affecting the modular distance learning in Science of the Grade 10 students of Magallanes National Vocational High School, School Year 2021-2022. Factors being considered are: Learning Environment, Learning Preferences, Parent’s Support, and Teacher’s Support. There were 156 Grade 10 students who served as the respondents of the study. The findings in this paper were gathered from the survey questionnaire given to the identified respondents. On the other hand, the performance level of the students was based on the summative test given during the first quarter of the school year.