Technological application in lesson delivery plays an important role in the learnings of today’s youth. Thus, this study was conducted to have a better understanding of the relationship of learning gains as perceived by the learners and their interest through the use of student-created video in the subject General Biology 2 in General Academic Track. Specifically, the researcher intended to measure the level of perceived learning gains and interests on the use of SCV after its utilization, and know if there is significant relationship that would exist between the two variables. This study employed Correlational Quantitative Research Design. The samples were purposively selected and comprised of 24 respondents, of whom were 5 males and 19 females from Gabao National High School in Gabao, Irosin, Sorsogon. Based on the analysis and interpretation of the data, it was found out that learners had shown high interest on the use of SCV. In terms of perceived learning gains, learners generally admitted that they had improved their understanding of the concepts in General Biology 2 after making their own video lessons. On the other hand, the study also revealed that there was a significant and positive relationship between the perceived learning gains and the student interest through the p-value of less than α at 0.05 level and r value of 0.753. This means that the increased level of interest of students towards the subject matter, after video making of Biology concepts, advantageously affected their learnings and their academic performance in general.