The study aimed to investigate which domain of career development learning and employability skills significantly influences the career competencies of senior high school students in the selected high schools in Davao del Sur for the school year 2019-2020. Using an adapted standardized questionnaire, the researcher surveyed 294 respondents. A random sampling technique was used to identify research respondents. The mean, Pearson r, and multiple regression were used to examine the data gathered. Results of the study revealed that the level of career development learning and career competencies individually obtained a high assessment. Meanwhile, all measures of employability skills obtained a high assessment except for human skills, which were assessed very highly by the respondents. Each indicator of employability skill was a determinant of employability; hence, no overall mean was measured. Further, when analyzed as to the relationship between variables, the result suggests a significant correlation between career development learning and career competencies and between employability and career competencies. Alternatively, when regressed, the individual domains of employability skills that significantly influence career competencies are human, leadership, and communication skills. Among the three, human skills best influence career competencies.